August 1, 1983AJP Heart and Circulatory Physiology

The cardiac cycle: regulation and energy oscillations

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Population

Isolated working rat hearts

Comparison

Glucose perfusion under maximal stress… vs Pyruvate perfusion

Design

Preclinical

Authors

JWJoan Wikman‐CoffeltUniversity of California, San Francisco RSRichard E. SieversHeart Failure / Cardiomyopathy RCR. J. CoffeltUniversity of California, San Francisco

Discussion

Member takes

Implication

No clinical implications yet; leaves open translation of ADP recycling to human myocardial energetics.

Structured PICO

Population

Isolated working rat hearts

Intervention

Glucose perfusion under maximal stress (afterload chamber set at 110 mmHg, perfusate containing 3.5 mM free calcium and 5 X 10(-9) M isoproterenol)

Comparator

Pyruvate perfusion

Outcome

Cyclical changes in energy-related metabolites (ATP, phosphocreatine, glucose 6-phosphate, pyruvate, ADP, inorganic phosphate, creatine, cAMP) during various phases of the cardiac cyclesurrogate

This preclinical study demonstrates that the free energy of ATP hydrolysis is preserved during cardiac contraction through continuous binding and recycling of ADP in maximally stressed glucose-perfused rat hearts.

Cite This Study

Wikman‐Coffelt et al. (1983) studied this question.

synapsesocial.com/papers/6a83871fdaf812a7fbcd7cd0 https://doi.org/10.1152/ajpheart.1983.245.2.h354

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The cardiac cycle: regulation and energy oscillations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The cardiac cycle: regulation and energy oscillations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider