Population
Isolated rat hearts
Comparison
Acute or chronic myocardial stress vs Control conditions
Design
Preclinical
Authors
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Tight regulation of myocardial energetics persists under stress in isolated hearts; leaves open in vivo relevance and clinical translation.
In an isolated rat heart model, concentrations of high-energy phosphates over the cardiac cycle are tightly regulated and their small cyclical changes are not accentuated by acute or chronic stress.
Illing et al. (1998) studied this question.
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