High‐energy phosphates metabolism and recovery in reperfused ischaemic hearts
Population
73 isolated rat hearts
Comparison
20 min of low-flow ischaemia or hypoxaemia… vs Comparison between ischaemic vs hypoxaemic and…
Design
Preclinical
Follow-up
20 min oxygen shortage followed by 20 min recovery
Authors
Discussion
Loading...
Member takes
Implication
May support ATP preservation for recovery in ischaemic hearts; leaves open translation to clinical reperfusion.
Structured PICO
P
Population
73 isolated rat hearts
I
Intervention
20 min of low-flow ischaemia or hypoxaemia, either spontaneously beating or paced to increase energy demand
C
Comparator
Comparison between ischaemic vs hypoxaemic and spontaneously beating vs paced groups
O
Outcome
Myocardial ATP, phosphocreatine, and their metabolites during oxygen shortage and recovery, and myocardial performancesurrogate
Maintenance of the ATP pool under low oxygen supply conditions, determined by energy demand and coronary flow, is essential for functional recovery in reperfused ischaemic hearts.
Cite This Study
Samaja et al. (1998) studied this question.