Why the study?
Does high glucose and insulin improve the energetic profile and functional recovery in isolated rat hearts during low-flow ischemia?
Population
Isolated blood-perfused rat hearts
Comparison
High glucose and insulin as substrate during 60… vs Control substrate
Design
Preclinical
Follow-up
90 minutes (60 minutes ischemia, 30 minutes reperfusion)
Authors
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Should not change AMI practice; hypothesis-generating for glucose-insulin support in ischemia.
Does high glucose and insulin improve the energetic profile and functional recovery in isolated rat hearts during low-flow ischemia?
High glucose and insulin supplementation during low-flow ischemia improves myocardial energetics and functional recovery in a rat model, providing mechanistic support for its use in acute myocardial infarction.
Cave et al. (2000) studied this question.
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