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January 12, 1981Acta Medica Scandinavica

Energy Metabolism in the Reversible and Irreversible Phases of Severe Myocardial Ischemia

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Population

Ischemic dog hearts (in vivo coronary occlusion and in vitro total ischemia models)

Comparison

Severe ischemia and total ischemia with and… vs Control tissue

Design

Preclinical

Follow-up

Up to 4 days (post-reperfusion)

Authors

KRKeith A. ReimerNorthwestern UniversityRJRobert B. JenningsUniversité Claude Bernard Lyon 1

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Implication

ATP depletion below 2.0 μmoles/g tied to irreversible canine injury; leaves open translation to human ischemia thresholds and reperfusion timing.

Key Points

  • This research aims to investigate the energy metabolism changes during reversible and irreversible myocardial ischemia.
  • Analyzed high energy phosphate utilization in ischemic dog hearts under in vivo coronary occlusion and in vitro total ischemia.
  • Measured ATP and lactate levels to assess anaerobic glycolysis and nucleotide recovery post-ischemia.
  • Incubated control tissue in phosphate medium to evaluate ATP levels and cellular viability.
  • ATP levels dropped to 35% of control at 15 minutes and below 10% at 40 minutes, marking irreversible injury.
  • Cellular abnormalities appeared when ATP was less than 2.0 μmoles/g dry weight, affecting high energy phosphate resynthesis.
  • Reperfusion after ischemia resulted in nucleotide losses to circulation and incomplete adenine nucleotide recovery for up to four days.

Structured PICO

P
Population
Ischemic dog hearts (in vivo coronary occlusion and in vitro total ischemia models)
I
Intervention
Severe ischemia (in vivo) and total ischemia (in vitro) with and without reperfusion
C
Comparator
Control tissue
O
Outcome
High energy phosphate (HEP) utilization and depletion, and transition from reversible to irreversible cell injurysurrogate

In a canine model of myocardial ischemia, irreversible cell injury is closely associated with marked ATP depletion and the subsequent failure of the tissue to regenerate high energy phosphates or maintain cell volume and ionic regulation.

Cite This Study

Reimer et al. (1981) studied this question.

synapsesocial.com/papers/6a711e358031ec7bb1dcc59bhttps://doi.org/10.1111/j.0954-6820.1981.tb03628.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial creatine phosphate and nucleotides in anoxic cardiac arrest and recovery1961 · 95 citations
  2. 2Effects of Acidosis on the Performance and Metabolism of the Anoxic Heart1969 · 25 citations
  3. 3De Novo Synthesis of Myocardial Adenine Nucleotides in the Rat1973 · 199 citations
  4. 4Persistence of myocardial injury following brief periods of coronary occlusion1976 · 143 citations
  5. 5Histopathology of the conduction system in the sudden infant death syndrome.1976 · 112 citations