Why the study?
Does the accumulation of glycolytic products and extracellular calcium accelerate irreversible damage to ischemic myocardium independently of ATP levels in perfused rat hearts?
Population
Perfused rat hearts subjected to 30 minutes of ischemia and subsequent reperfusion
Comparison
Accumulation of glycolytic products and… vs Hearts with depleted tissue glycogen or lower…
Design
Preclinical
Authors
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Lactate accumulation during ischemia inversely predicts ventricular recovery independent of ATP in rat hearts; hypothesis-generating for glycolytic products in clinical ischemic injury.
Does the accumulation of glycolytic products and extracellular calcium accelerate irreversible damage to ischemic myocardium independently of ATP levels in perfused rat hearts?
Anaerobic glycolytic products and extracellular calcium play a major role in irreversible ischemic myocardial damage, independent of tissue adenine nucleotide loss.
Neely et al. (1984) studied this question.
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