Relation between glycolysis and calcium homeostasis in postischemic myocardium.
Why the study?
Does inhibition of glycolysis impair calcium homeostasis and functional recovery in postischemic isolated rabbit hearts?
Population
Isolated perfused rabbit hearts subjected to 20 minutes of global zero-flow ischemia
Comparison
Inhibition of glycolysis with iodoacetate during… vs Reperfusion with intact glycolysis
Design
Preclinical
Follow-up
60 minutes of reperfusion
Authors
Discussion
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Member takes
Implication
Glycolysis inhibition during reperfusion may worsen calcium overload and impair recovery in ischemic myocardium; leaves open whether metabolic modulation improves clinical outcomes.
Structured PICO
Does inhibition of glycolysis impair calcium homeostasis and functional recovery in postischemic isolated rabbit hearts?
P
Population
Isolated perfused rabbit hearts subjected to 20 minutes of global zero-flow ischemia
I
Intervention
Inhibition of glycolysis with iodoacetate during reperfusion
C
Comparator
Reperfusion with intact glycolysis (5 mM pyruvate as carbon substrate)
O
Outcome
Intracellular calcium concentration ([Ca2+]i) and functional recovery (rate/pressure product and left ventricular end-diastolic pressure)surrogate
Glycolysis plays a critical role in restoring calcium homeostasis and functional recovery in postischemic myocardium.
Cite This Study
Jeremy et al. (1992) studied this question.