Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1985Annual Review of Physiology

Nucleotide Metabolism and Cellular Damage in Myocardial Ischemia

View Full Paper
Ask AI
Bookmark
Share

Population

Dog heart model of myocardial ischemia

Comparison

Myocardial anoxia or ischemia vs Control tissue

Design

Review

Authors

RJRobert B. JenningsUniversité Claude Bernard Lyon 1CSCharles SteenbergenCross-Cutting Cardiology

Discussion

Loading...

Member takes

Implication

ATP thresholds may guide viability assessment in ischemia; leaves open whether nucleotide preservation alters clinical outcomes.

Structured PICO

P
Population
Dog heart model of myocardial ischemia
I
Intervention
Myocardial anoxia or ischemia
C
Comparator
Control tissue
O
Outcome
Depletion of ATP and total adenine nucleotide poolsurrogate

Myocardial ischemia leads to progressive depletion of ATP and the adenine nucleotide pool, with irreversible cell death associated with near-complete ATP loss.

Cite This Study

Jennings et al. (1985) studied this question.

synapsesocial.com/papers/6a72a2bf5671bbf00bc31a58https://doi.org/10.1146/annurev.ph.47.030185.003455
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolism and the electrical activity of anoxic ventricular muscle1973 · 181 citations
  2. 2Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.1984 · 908 citations
  3. 3Effect of acute coronary artery occlusion on local myocardial extracellular K+ activity in swine.1980 · 468 citations
  4. 4Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum1979 · 725 citations
  5. 5Studies of acidosis in the ischaemic heart by phosphorus nuclear magnetic resonance1979 · 483 citations