What question did this study set out to answer?

To evaluate the effects of one hour of mild and moderate reductions in coronary blood flow on myocardial high-energy phosphate levels.

December 1, 1990Circulation ResearchOpen Access

Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia.

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Why the study?

Does 1 hour of mild to moderate ischemia alter myocardial high-energy phosphate levels in anesthetized pigs?

Key Points

To evaluate the effects of one hour of mild and moderate reductions in coronary blood flow on myocardial high-energy phosphate levels.
Instrumented 30 anesthetized pigs with left anterior descending arterial and venous catheters, wall thickness crystals, and an occluder.
Assigned animals to moderate ischemia with a 22% overall flow reduction (n=10), marked ischemia with a 43% transmural flow reduction (n=7), or two control groups (n=13).
Measured myocardial blood flow using radioactive microspheres and analyzed high-energy phosphates via serial myocardial biopsies over 1 hour.
In pigs with a 22% flow reduction, subendocardial phosphocreatine decreased from 7.6 to 3.8 µmol/g wet weight at 5 minutes (p < 0.005 vs control) but returned to 7.9 µmol/g at 60 minutes (p = NS).
Subendocardial ATP progressively declined from 4.3 to 2.1 µmol/g wet weight at 60 minutes of ischemia (p < 0.001 vs control).
Phosphocreatine similarly regenerated in pigs with a 43% transmural flow reduction (66% subendocardial reduction), whereas control animals (n=13) showed no significant changes in ATP or phosphocreatine.

Structured PICO

Does 1 hour of mild to moderate ischemia alter myocardial high-energy phosphate levels in anesthetized pigs?

Population

30 anesthetized pigs instrumented with left anterior descending arterial and venous catheters, crystals for instantaneous wall thickness, and a fluid-filled occluder.

Intervention

1 hour of mild (22% overall reduction, 48% subendocardial reduction) and moderate (43% transmural reduction, 66% subendocardial reduction) reductions in coronary blood flow.

Comparator

Two different control groups (n = 13 pigs) without induced ischemia.

Outcome

Myocardial high-energy phosphate levels (phosphocreatine and ATP) measured via myocardial biopsies over 1 hour.surrogate

Phosphocreatine levels in ischemic myocardium regenerate to normal levels by 60 minutes despite ongoing moderate ischemia and persistently low ATP levels.

Discussion

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Implication

Suggests metabolic adaptation during moderate ischemia in pigs; leaves open translation to human myocardium.

Cite This Study

Pantely et al. (1990) studied this question.

synapsesocial.com/papers/6a89c105a90c2f4c44fba5cc https://doi.org/10.1161/01.res.67.6.1481

View Full Paper

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Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider