Why the study?
Does perfusion with palmitate or acetate alter energy metabolism and coronary flow compared to glucose in isolated rat hearts?
Population
Isolated perfused rat hearts
Comparison
Perfusion with palmitate or acetate vs Perfusion with glucose
Design
Preclinical
Authors
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Substrate effects on myocardial energetics should not guide clinical decisions; leaves open translation to human coronary flow regulation.
Does perfusion with palmitate or acetate alter energy metabolism and coronary flow compared to glucose in isolated rat hearts?
Substrate source significantly alters energy metabolism and coronary flow in isolated rat hearts, with the cytosolic [ATP]free/[ADP]free[Pi] ratio acting as a major determinant of O2 consumption and coronary flow.
Starnes et al. (1985) studied this question.
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