What question did this study set out to answer?

To evaluate whether free fatty acids and lactate alter myocardial oxygen consumption, mechanical efficiency, or hemodynamic performance in isolated hearts.

June 1, 1983The Journal of PhysiologyOpen Access

The effect of palmitate and lactate on mechanical performance and metabolism of cat and rat myocardium.

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Why the study?

Does palmitate or lactate alter mechanical performance and metabolism in isolated cat and rat myocardium compared to glucose alone?

Population

14 isolated ejecting hearts perfused with a suspension of red cells in Tyrode solution, and isolated rat…

Comparison

Glucose plus free fatty acid or additional lactate vs Glucose alone or no substrate changes (controls)

Design

Preclinical

Authors

ADA. J. Drake‐HollandSt George's Hospital GEG ElzingaUniversity of Amsterdam MNMark I. M. NobleElectrophysiology

Discussion

Member takes

Implication

No oxygen-wasting effect of palmitate or lactate in isolated myocardium; leaves open in vivo or human translation.

Key Points

To evaluate whether free fatty acids and lactate alter myocardial oxygen consumption, mechanical efficiency, or hemodynamic performance in isolated hearts.
Perfused 14 isolated ejecting hearts with red cells in Tyrode solution under fixed mean aortic pressure across glucose alone, glucose plus palmitate (N=5), additional lactate (N=5), or unmanipulated controls (N=4).
Assessed mechanical performance in isolated rat trabeculae during exogenous substrate deprivation and following reintroduction of glucose, palmitate, or lactate.
Switching perfusion media produced only transient cardiac output changes, yielding no consistent steady-state alterations in myocardial oxygen consumption, mean external power, cardiac output, efficiency, or coronary blood flow.
Isolated rat trabeculae sustained stable mechanical performance for approximately 10 minutes under substrate deprivation, and subsequent mechanical decline was reversed by any of the three exogenous substrates.

Structured PICO

Does palmitate or lactate alter mechanical performance and metabolism in isolated cat and rat myocardium compared to glucose alone?

Population

14 isolated ejecting hearts (cat and rat myocardium) perfused with a suspension of red cells in Tyrode solution, and isolated rat trabeculae.

Intervention

Glucose plus free fatty acid (palmitate) or additional lactate

Comparator

Glucose alone or no substrate changes (controls)

Outcome

Mechanical performance and metabolism (myocardial oxygen consumption, mean external power, efficiency, cardiac output, coronary blood flow)surrogate

Palmitate and lactate do not have an oxygen-wasting or deleterious effect on mechanical performance in isolated cat and rat myocardium.

Cite This Study

Drake‐Holland et al. (1983) studied this question.

synapsesocial.com/papers/6a7f3324da7edfc28fb3aa97 https://doi.org/10.1113/jphysiol.1983.sp014698

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The effect of palmitate and lactate on mechanical performance and metabolism of cat and rat myocardium.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The effect of palmitate and lactate on mechanical performance and metabolism of cat and rat myocardium.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider