April 1, 1986Cardiovascular Research
Exogenous substrate preference of the post-ischaemic myocardium
Population
Experimental model of myocardium subjected to severe but reversible global ischaemic stress
Comparison
Post-ischaemic state with increased plasma… vs Pre-ischaemic state with increased plasma…
Design
Preclinical
Authors
Discussion
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Implication
Post-ischaemic fatty acid oxidation shift is hypothesis-generating in animals; leaves open human relevance and therapeutic targeting.
Structured PICO
P
Population
Experimental model of myocardium subjected to severe but reversible global ischaemic stress (continuous hypothermic electromechanical arrest for 4 hours by aortic cross clamping and multidose potassium cardioplegia)
I
Intervention
Post-ischaemic state with increased plasma lactate concentrations (8.47-11.17 mmol/L)
C
Comparator
Pre-ischaemic state with increased plasma lactate concentration (3.9-5.8 mmol/L)
O
Outcome
Exogenous free fatty acid oxidation rate and contribution to total carbon dioxide productionsurrogate
After severe but reversible ischaemic stress, the myocardium shifts its substrate preference to greater oxidation of exogenous free fatty acids despite increased plasma lactate concentrations.
Cite This Study
Mickle et al. (1986) studied this question.