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July 1, 1969Journal of Clinical InvestigationOpen Access

Free fatty acid metabolism of the human heart at rest

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Population

13 subjects over 40 years of age undergoing diagnostic cardiac catheterization after an overnight fast.

Design

Cross-sectional

Authors

AMAlbert S. MostNBNorman BrachfeldRGRichard Gorlin

Discussion

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Overview

Supports FFA dominance in fasting human cardiac metabolism; leaves open therapeutic targeting in HF or ischemia.

Structured PICO

P
Population
13 subjects over 40 years of age undergoing diagnostic cardiac catheterization after an overnight fast (>14 hours).
I
Intervention
Intravenous infusion of 1-palmitate-14C (50 μCi) over 20-60 minutes with arterial and coronary sinus blood sampling.
O
Outcome
Myocardial fractional extraction and fractional oxidation of free fatty acids (FFA), and their contribution to myocardial oxygen consumption.surrogate

This physiological study demonstrates that free fatty acids are a major energy substrate for the fasting human heart at rest, accounting for over half of its oxygen consumption.

Limitations

  • One subject had documented myocardial ischemia during the study and had to be treated separately.
  • Steady-state 14CO2 production was not fully achieved with shorter infusion times, potentially underestimating fractional oxidation.

Cite This Study

Most et al. (1969) studied this question.

synapsesocial.com/papers/6a73320dfeeedbd807c232afhttps://doi.org/10.1172/jci106082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial Lipid and Carbohydrate Metabolism in Healthy, Fasting Men at Rest: Studies During Continuous Infusion of <sup>3</sup>H‐Palmitate1972 · 80 citations
  2. 2FATTY ACID AS A DETERMINANT OF MYOCARDIAL SUBSTRATE AND OXYGEN METABOLISM IN MAN AT REST AND DURING PROLONGED EXERCISE1973 · 30 citations
  3. 3Myocardial turnover of plasma free fatty acids during angina pectoris induced by atrial pacing1988 · 7 citations
  4. 4Metabolism of free fatty acids by myocardium and kidney1964 · 78 citations
  5. 5Metabolic fate of extracted glucose in normal human myocardium.1985 · 206 citations