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January 1, 1964American Journal of Physiology-Legacy Content

Metabolism of free fatty acids by myocardium and kidney

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Key result

Canine myocardium extracts ~40% of arterial free fatty acids while kidneys remove only palmitic acid.

Authors

MGMartin GoldJSJohn J. Spitzer

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Overview

Demonstrates organ-specific fatty acid extraction in dogs; leaves open translation to human myocardial and renal metabolism.

PICO

P
Population
Dogs receiving an infusion of I-C14-palmitate, oleate, linoleate, or octanoate to study myocardial and renal removal and oxidation of plasma free fatty acids.
I
Intervention / Comparator
Infusion of I-C14-palmitate, oleate, linoleate, or octanoate
O
Primary Outcome
Myocardial and renal removal and oxidation of plasma free fatty acids

Cite This Study

Gold et al. (1964) studied this question. Infusion of I-C14-palmitate, oleate, linoleate, or octanoate was evaluated on Myocardial and renal removal and oxidation of plasma free fatty acids. In dogs, the myocardium extracted about 40% of total arterial free fatty acids with some oxidized to CO2, while the kidney showed consistent net removal only for palmitic acid.

synapsesocial.com/papers/6aa16c669a899fca14ed7091https://doi.org/10.1152/ajplegacy.1964.206.1.153
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Free fatty acid metabolism of the human heart at rest1969 · 81 citations
  2. 2Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs1971 · 309 citations
  3. 3Failure of Free Fatty Acids to Influence Myocardial Oxygen Consumption in the Intact, Anesthetized Dog2008 · 13 citations
  4. 4Competition between palmitate and ketone bodies as fuels for the heart: study with positron emission tomography1993 · 25 citations
  5. 5Effects of Free Fatty Acids on Experimentally Infarcted Myocardium1979