Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1979Japanese Heart JournalOpen Access

Effects of Free Fatty Acids on Experimentally Infarcted Myocardium

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does free fatty acid infusion deteriorate cardiac dynamics and mitochondrial function in experimentally infarcted myocardium in dogs?

Population

28 healthy mongrel dogs weighing 8-12 Kg with experimentally induced myocardial infarction via left anterior…

Comparison

Intravenous infusion of palmitic acid, oleic… vs Non-infusion control group and saline infusion…

Design

Preclinical

Follow-up

60 minutes

Authors

HHHiroshi HasegawaGunma UniversityTITaro IshiyamaSaba University School of MedicineYMYoshiharu MoritaOsaka Rosai Hospital

Discussion

Loading...

Member takes

Overview

Oleic acid may impair contractility and mitochondrial respiration in ischemic myocardium; leaves open whether FFA modulation improves outcomes in acute infarction.

Structured PICO

Does free fatty acid infusion deteriorate cardiac dynamics and mitochondrial function in experimentally infarcted myocardium in dogs?

P
Population
28 healthy mongrel dogs weighing 8-12 Kg with experimentally induced myocardial infarction via left anterior descending coronary artery ligation for 60 minutes.
I
Intervention
Intravenous infusion of palmitic acid (30 μM/Kg/min), oleic acid (30 μM/Kg/min), or 10% glucose with insulin (0.17 ml/Kg/min) started 15 min before coronary ligation and continued for 30 min.
C
Comparator
Non-infusion control group and saline infusion control group (0.3 ml/Kg/min).
O
Outcome
Cardiac dynamics (isometric time tension index), infarct size (epicardial ST-segment elevation), and mitochondrial function (respiratory control index, oxygen consumption rate).surrogate

High levels of serum free fatty acids, particularly unsaturated oleic acid, exert negative inotropic effects and impair mitochondrial respiratory function in ischemic myocardium.

Cite This Study

Hasegawa et al. (1979) studied this question.

synapsesocial.com/papers/6a7f3324da7edfc28fb3aa9dhttps://doi.org/10.1536/ihj.20.557
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Glucose-Insulin-Potassium Infusion on Myocardial Infarction following Experimental Coronary Artery Occlusion1972 · 295 citations
  2. 2The Role of Free Fatty Acids in the Production of Ventricular Arrhythmias after Acute Coronary Artery Occlusion1971 · 190 citations
  3. 3EFFECTS OF METABOLIC AND PHARMACOLOGIC INTERVENTIONS ON MYOCARDIAL INFARCT SIZE FOLLOWING CORONARY OCCLUSION*1976 · 65 citations
  4. 4Mitochondrial Respiration of Experimentally Produced Ischemic Heart Muscle in Dogs1967 · 7 citations