Why the study?
Does increased myocardial uptake of free fatty acids induced by intravenous fat emulsion affect myocardial function and oxygen consumption in anesthetized intact dogs?
Does increased myocardial uptake of free fatty acids induced by intravenous fat emulsion affect myocardial function and oxygen consumption in anesthetized intact dogs?
Increased myocardial uptake of free fatty acids significantly increases myocardial oxygen consumption without altering myocardial hemodynamics or function in an intact dog model.
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May raise myocardial O2 demand without hemodynamic effects in dogs; leaves open relevance to human cardiac energetics.
A B S T R A C T Myocardial function and oxygen con- sumption (MV02) were studied during increased myocardial uptake of free fatty acids (FFA) induced by in- travenous infusion of a fat emulsion (Intralipid) after heparinization in anesthetized and intact dogs. During raised myocardial uptake of FFA, MV02 increased in all experiments. On the average, MV02 rose from 8.6 to 10.7 ml/min. 100 g, or 26% (P <0.001). This was mainly due to elevated myocardial oxygen extraction, as myocardial blood flow was unchanged, or increased slightly. In the recovery period, MV02 returned to normal. Left ventricular pressure, the maximal rate of rise of left ventricular pressure (dP/dt), heart rate, and cardiac output remained unchanged during the raised myocardial uptake of FFA.
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Ole D. Μjøs (1971) studied this question.
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