What does this research mean for the field?

Excess free fatty acids significantly impair mechanical and metabolic cardiac function in both normal and ischemic myocardium, exacerbating ischemic deterioration and causing accumulations of tissue acyl CoA and acyl carnitine derivatives. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1978Circulation ResearchOpen Access

Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine.

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Why the study?

Does excess free fatty acids impair mechanical and metabolic function in normal and ischemic myocardium in swine?

Population

n=24 globally perfused working swine hearts

Comparison

Heparin and 10% fat emulsion to produce a 3- to… vs Untreated hearts with normal free fatty acid…

Design

Preclinical

Authors

ALA. J. LiedtkeUniversity Hospital of Basel SNS. H. NellisPennsylvania State University JNJ. R. NeelyUniversity of California, Davis

Discussion

Member takes

Implication

Excess FFA impairs swine myocardial function; hypothesis-generating for human ischemia, requiring clinical validation.

Structured PICO

Does excess free fatty acids impair mechanical and metabolic function in normal and ischemic myocardium in swine?

Population

n=24 globally perfused working swine hearts

Intervention

Heparin and 10% fat emulsion (Intralipid) to produce a 3- to 5-fold elevation in serum free fatty acid (FFA) levels

Comparator

Untreated hearts with normal free fatty acid levels

Outcome

Mechanical and metabolic functions including aortic pressure, left ventricular systolic pressure, left ventricular work, epicardial motion, and myocardial oxygen consumptionsurrogate

Excess free fatty acids significantly impair cardiac mechanical function and alter metabolic profiles in both normal and ischemic swine myocardium.

Cite This Study

Liedtke et al. (1978) studied this question.

synapsesocial.com/papers/6a15378d79ff98d0de4e44de https://doi.org/10.1161/01.res.43.4.652

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Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider