Why the study?
Does an acute elevation of arterial free fatty acids affect myocardial oxygen consumption in intact, anesthetized dogs?
Population
Intact, anesthetized dogs (n=7)
Comparison
Acute elevation of arterial free fatty acids via… vs Baseline measurements prior to FFA elevation
Design
Preclinical
Follow-up
30 minutes
Authors
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Should not guide clinical FFA management; leaves open translation to human coronary physiology or chronic exposure.
Does an acute elevation of arterial free fatty acids affect myocardial oxygen consumption in intact, anesthetized dogs?
Acute elevation of arterial free fatty acids within the physiologic range does not significantly alter myocardial oxygen consumption in an intact canine model.
Most et al. (2008) studied this question.
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