What question did this study set out to answer?

To determine whether inhibiting acylcarnitine accumulation with 2-tetradecylglycidic acid preserves myocardial function in intact hearts during fatty acid excess under aerobic and ischemic conditions.

September 1, 1986AJP Heart and Circulatory Physiology

Effects of 2-tetradecylglycidic acid on myocardial function in swine hearts

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Why the study?

Does 2-tetradecylglycidic acid improve myocardial function and alter metabolism in swine hearts during fatty acid excess?

Population

19 intact working swine hearts perfused extracorporeally with whole blood, with serum fatty acids augmented…

Comparison

2-tetradecylglycidic acid (TDGA) vs Placebo-treated control group

Design

Preclinical

Follow-up

90 min

Authors

WMWilliam P. MillerMassachusetts Eye and Ear Infirmary ALA. J. LiedtkeUniversity Hospital of Basel SNS. H. NellisPennsylvania State University

Discussion

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Implication

Hypothesis-generating for metabolic modulation in ischemia; leaves open translation beyond swine models of fatty acid excess.

Key Points

To determine whether inhibiting acylcarnitine accumulation with 2-tetradecylglycidic acid preserves myocardial function in intact hearts during fatty acid excess under aerobic and ischemic conditions.
Extracorporeal whole-blood perfusion of intact working swine hearts with 3- to 4-fold elevated serum fatty acids, comparing TDGA treatment (n = 10) to placebo control (n = 9) over 90 minutes.
Fatty acid oxidation was measured using intracoronary [U-14C]palmitate infusion, regional myocardial function was tracked with ultrasonic crystals, and a 50% reduction in coronary blood flow was imposed during the final 30 minutes.
TDGA significantly decreased 14CO2 production during aerobic perfusion, significantly reduced myocardial acylcarnitine levels, and significantly elevated acetyl-CoA concentrations in both aerobic and ischemic tissue.
Inhibition of fatty acid metabolism during aerobic flow increased regional myocardial shortening at identical oxygen consumption levels, reflecting enhanced carbohydrate utilization.
During 30 minutes of ischemia, mechanical impairment was similar between groups, but myocardial lactate production was 70% lower in the TDGA-treated cohort (P < 0.025).

Structured PICO

Does 2-tetradecylglycidic acid improve myocardial function and alter metabolism in swine hearts during fatty acid excess?

Population

19 intact working swine hearts perfused extracorporeally with whole blood, with serum fatty acids augmented three- to fourfold

Intervention

2-tetradecylglycidic acid (TDGA)

Comparator

Placebo-treated control group

Outcome

Regional myocardial function (shortening) and fatty acid metabolism (14CO2 production, acylcarnitine, acetyl-CoA, lactate) over 90 min (60 min aerobic, 30 min ischemia)surrogate

In a swine model of fatty acid excess, TDGA inhibited fatty acid metabolism, enhanced carbohydrate utilization, and improved regional myocardial shortening during aerobic perfusion.

Cite This Study

Miller et al. (1986) studied this question.

synapsesocial.com/papers/6a984e657f1bd40ee0e3652a https://doi.org/10.1152/ajpheart.1986.251.3.h547

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Effects of 2-tetradecylglycidic acid on myocardial function in swine hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of 2-tetradecylglycidic acid on myocardial function in swine hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider