Why the study?
Does buffered pyruvate improve regional cardiac function in moderate, short-term ischemia in swine hearts?
Population
21 swine hearts, model of moderate regional ischemia
Comparison
Buffered pyruvate (pyruvate with Tris buffer) vs Untreated myocardium
Design
Preclinical
Follow-up
15 minutes of ischemia, 5 minutes of reflow
Authors
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Buffered pyruvate improves regional function in swine ischemia; hypothesis-generating for metabolic support in human acute coronary syndromes.
Does buffered pyruvate improve regional cardiac function in moderate, short-term ischemia in swine hearts?
Buffered pyruvate improves regional mechanical motion and increases both aerobic and anaerobic metabolism during moderate, short-term ischemia in swine hearts.
Liedtke et al. (1978) studied this question.
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