Why the study?
Does suppression of fatty acid utilization with oxfenicine affect mechanical recovery and substrate oxidation during early myocardial reperfusion in swine hearts?
Population
Working swine hearts (n=15) subjected to ischemia and reperfusion.
Comparison
Oxfenicine to suppress fatty acid utilization… vs Control group receiving Intralipid with heparin…
Design
Preclinical
Follow-up
50 minutes of reperfusion
Authors
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Impaired mechanical recovery with oxfenicine in swine reperfusion; hypothesis-generating for metabolic interventions and should not yet inform practice.
Does suppression of fatty acid utilization with oxfenicine affect mechanical recovery and substrate oxidation during early myocardial reperfusion in swine hearts?
Suppression of fatty acid utilization during early myocardial reperfusion impairs mechanical recovery despite increasing carbohydrate oxidation in a swine model.
Renstrøm et al. (1990) studied this question.
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