Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 19, 2003Cardiovascular ResearchOpen Access

Oxfenicine significantly lowered lactate output integrals (0.60+/-0.11 vs. 1.11+/-0.23 mmol) and increased anterior wall power index (1.30+/-0.11% vs. 0.95+/-0.17%) compared to vehicle.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does partial inhibition of fatty acid oxidation with oxfenicine reduce lactate production and increase regional myocardial power during demand-induced ischemia in a swine model?

Population

Anesthetized open-chest swine with demand-induced ischemia (produced by reducing left anterior descending…

Comparison

Oxfenicine (2 mmol l(-1)) vs Vehicle

Design

Preclinical

Follow-up

20 minutes

Authors

MCMary H.H. Chandler

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for metabolic modulation in ischemia; leaves open clinical translation pending human trials.

Structured PICO

Does partial inhibition of fatty acid oxidation with oxfenicine reduce lactate production and increase regional myocardial power during demand-induced ischemia in a swine model?

P
Population
Anesthetized open-chest swine with demand-induced ischemia (produced by reducing left anterior descending coronary artery flow by 20% and increasing heart rate and contractility with dobutamine 15 microg kg(-1) min(-1) i.v. for 20 min), n=14
I
Intervention
Oxfenicine (2 mmol l(-1))
C
Comparator
Vehicle
O
Outcome
Lactate production and regional myocardial power (anterior wall power index)surrogate

Partial inhibition of fatty acid oxidation with oxfenicine reduces non-oxidative glycolysis and improves regional contractile power and efficiency during demand-induced ischemia in a preclinical swine model.

Cite This Study

Mary H.H. Chandler (2003) studied this question.

synapsesocial.com/papers/6a82d4f38757ed1e60134770https://doi.org/10.1016/s0008-6363(03)00327-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of reducing fatty acid metabolism on mechanical function in regionally ischemic hearts1984 · 59 citations
  2. 2Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation2007 · 35 citations
  3. 3Beneficial Effects of Oxfenicine on the Hypoxic Rat Atria1995 · 10 citations
  4. 4Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia2003 · 29 citations
  5. 5Beneficial effect of enhanced myocardial carbohydrate utilisation after oxfenicine (L-hydroxyphenylglycine) in angina pectoris1980 · 50 citations