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May 1, 2003AJP Heart and Circulatory Physiology

Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia

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Why the study?

Does hyperglycemia with or without oxfenicine improve myocardial metabolism and function during demand-induced ischemia in swine hearts?

Population

Anesthetized open-chest swine hearts

Comparison

Hyperglycemia alone or Hyperglycemia + oxfenicine vs Control (CTRL)

Design

Preclinical

Authors

PCPedro N. ChavezWSWilliam C. StanleyTMTracy A McElfresh

Discussion

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Overview

Does not support clinical use; leaves open whether oxfenicine with hyperglycemia benefits human demand ischemia.

Structured PICO

Does hyperglycemia with or without oxfenicine improve myocardial metabolism and function during demand-induced ischemia in swine hearts?

P
Population
Anesthetized open-chest swine hearts
I
Intervention
Hyperglycemia (HG) alone or Hyperglycemia + oxfenicine (HG + Oxf)
C
Comparator
Control (CTRL)
O
Outcome
Myocardial lactate production, glucose oxidation, and energy efficiency during aerobic conditions and demand-induced ischemiasurrogate

Partial inhibition of free fatty acid oxidation combined with accelerated glycolysis reduces lactate production and enhances glucose oxidation during demand-induced ischemia in a swine model.

Cite This Study

Chavez et al. (2003) studied this question.

synapsesocial.com/papers/6a70a6def44fa9f079de54f8https://doi.org/10.1152/ajpheart.00974.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia2008 · 17 citations
  2. 2Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia2003 · 47 citations
  3. 3Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia2002 · 35 citations
  4. 4Different effects of interventions suppressing free fatty acid metabolism on myocardial ischemia1984 · 1 citations
  5. 5Glucose metabolism during ischemia due to excessive oxygen demand or altered coronary flow in the isolated arterially perfused rabbit septum.1981 · 33 citations