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May 1, 2002AJP Heart and Circulatory Physiology

Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia

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Population

Anesthetized open-chest swine hearts (n = 7)

Comparison

Intravenous dobutamine (15 microg x kg x min)… vs Baseline state prior to demand-induced ischemia

Design

Preclinical

Follow-up

20 min

Authors

MCMargaret P. ChandlerHHHazel HuangTMTracy A McElfresh

Discussion

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Overview

Swine ischemia data should not guide human care; leaves open whether modulating glucose or fatty acid use alters outcomes in demand ischemia.

Structured PICO

P
Population
Anesthetized open-chest swine hearts (n = 7)
I
Intervention
Intravenous dobutamine (15 microg x kg(-1) x min(-1)) and 20% reduction in left anterior descending (LAD) coronary artery flow for 20 min
C
Comparator
Baseline state prior to demand-induced ischemia
O
Outcome
Substrate uptake and oxidation (lactate, glucose, fatty acids) and myocardial oxygen consumption (MVO2)surrogate

In a swine model, demand-induced ischemia stimulates nonoxidative glycolysis and lactate production without affecting fatty acid uptake, despite a significant fall in exogenous fatty acid oxidation.

Cite This Study

Chandler et al. (2002) studied this question.

synapsesocial.com/papers/6a70a6def44fa9f079de54f9https://doi.org/10.1152/ajpheart.00976.2001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial metabolism during increased work states in the porcine left ventricle in vivo.1994 · 63 citations
  2. 2Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work1996 · 80 citations
  3. 3Effects of acute hyperglycemia on myocardial glycolytic activity in humans.1990 · 120 citations
  4. 4Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions Potential for pharmacological interventions1997 · 607 citations
  5. 5Metabolic fate of extracted glucose in normal human myocardium.1985 · 206 citations