Population
Isolated arterially perfused rabbit interventricular septa
Comparison
Supraphysiologic glucose during a 50-min period… vs Physiologic glucose during a 50-min period of…
Design
Preclinical
Follow-up
110 minutes (50-min hypoxia, 60-min reoxygenation)
Authors
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May warrant preclinical exploration of glucose in hypoxia; leaves open translation to human cardiac protection.
Enhanced utilization of exogenous glucose protects cardiac function during hypoxia through a mechanism independent of total glycolytic flux or high-energy phosphate levels.
Runnman et al. (1990) studied this question.
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