Why the study?
Does perhexiline or oxfenicine improve myocardial function and metabolism during low-flow ischemia/reperfusion in isolated rat hearts?
Population
Langendorff-perfused rat hearts subjected to 60 min of low-flow ischemia followed by 30 min of reperfusion
Comparison
Perhexiline or oxfenicine vs Control/untreated hearts (implied)
Design
Preclinical
Follow-up
90 minutes (60 min ischemia, 30 min reperfusion)
Authors
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Does not support clinical use in ischemia; hypothesis-generating for CPT inhibition attenuating diastolic dysfunction in vivo.
Does perhexiline or oxfenicine improve myocardial function and metabolism during low-flow ischemia/reperfusion in isolated rat hearts?
Perhexiline protects against diastolic dysfunction during ischemia in isolated rat hearts, likely through simultaneous inhibition of myocardial CPT-1 and CPT-2.
Kennedy et al. (2000) studied this question.
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