Effects of Perhexiline on Coronary Hemodynamic and Myocardial Metabolic Responses to Tachycardia
Key result
Perhexiline administration increased the heart rate threshold to tachycardia-induced angina pectoris from 123 to 134 beats/min (P<0.01) in patients with coronary heart disease.
Why the study?
Does perhexiline improve coronary hemodynamic and myocardial metabolic responses in patients with coronary heart disease during pacing-induced angina pectoris?
Population
21 patients with coronary heart disease during pacing-induced angina pectoris
Comparison
Perhexiline administration vs Baseline (before perhexiline administration)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Should not yet change angina management; hypothesis-generating for perhexiline's anti-ischemic effects, needing RCTs.
Structured PICO
Does perhexiline improve coronary hemodynamic and myocardial metabolic responses in patients with coronary heart disease during pacing-induced angina pectoris?
P
Population
21 patients with coronary heart disease evaluated during pacing-induced angina pectoris before and after perhexiline administration.
I
Intervention
Perhexiline administration
C
Comparator
Baseline (before perhexiline administration)
O
Outcome
Coronary hemodynamic and myocardial metabolic responses (including threshold to tachycardia-induced angina pectoris, anaerobic myocardial lactate extraction, myocardial oxygen extraction, and coronary flow)surrogate
Main Result
Absolute Event Rate: 134% vs 123%
p-value: p=<0.01
Perhexiline administration decreases myocardial ischemia by increasing the threshold to tachycardia-induced angina and enhancing myocardial oxygen extraction in patients with coronary heart disease.
Cite This Study
Pepine et al. (1974) studied Coronary heart disease with pacing-induced angina pectoris (n=21). Perhexiline vs. Before perhexiline administration was evaluated on Threshold to tachycardia-induced angina pectoris (heart rate) (p=<0.01). Perhexiline administration increased the heart rate threshold to tachycardia-induced angina pectoris from 123 to 134 beats/min (P<0.01) in patients with coronary heart disease.