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March 4, 2005Cardiovascular ResearchOpen Access

Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure

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Why the study?

Does CPT-I inhibition with oxfenicine prevent ventricular remodeling and delay decompensation in dogs with pacing-induced heart failure?

Population

27 dogs (9 normal, 9 untreated with pacing-induced heart failure, 9 heart failure treated with oxfenicine)

Comparison

Oxfenicine 65 mg/kg/day (a CPT-I inhibitor) vs Untreated pacing-induced heart failure dogs and…

Design

Preclinical

Follow-up

Up to terminal failure or 28 days of pacing

Authors

VLVincenzo LionettiALAxel LinkeMCMary H.H. Chandler

Discussion

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Overview

Hypothesis-generating in canine pacing HF; leaves open CPT-I inhibition translation to human therapy.

Structured PICO

Does CPT-I inhibition with oxfenicine prevent ventricular remodeling and delay decompensation in dogs with pacing-induced heart failure?

P
Population
27 dogs (9 normal, 9 untreated with pacing-induced heart failure, 9 heart failure treated with oxfenicine)
I
Intervention
Oxfenicine 65 mg/kg/day (a CPT-I inhibitor)
C
Comparator
Untreated pacing-induced heart failure dogs and normal dogs
O
Outcome
Time to terminal failure (LV end-diastolic pressure=25 mm Hg) and left ventricular remodeling at 28 dayssurrogate

Inhibition of CPT-I with oxfenicine delays decompensation and prevents left ventricular remodeling in a canine model of pacing-induced heart failure.

Limitations

  • Limited to an experimental model of disease

Cite This Study

Lionetti et al. (2005) studied this question.

synapsesocial.com/papers/6a7c6dbc24f98b6d3fc2d3d3https://doi.org/10.1016/j.cardiores.2005.02.004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CARNITINE PALMITOYL TRANSFERASE‐I INHIBITION IS NOT ASSOCIATED WITH CARDIAC HYPERTROPHY IN RATS FED A HIGH‐FAT DIET2006 · 36 citations
  2. 2Partial Fatty Acid Oxidation Inhibitors: A Potentially New Class of Drugs for Heart Failure2002 · 23 citations
  3. 3Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia2003 · 47 citations
  4. 4The PPARα Activator Fenofibrate Slows Down the Progression of the Left Ventricular Dysfunction in Porcine Tachycardia-Induced Cardiomyopathy2007 · 51 citations
  5. 5L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease2012 · 63 citations