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December 13, 2006Clinical and Experimental Pharmacology and Physiology

Carnitine Palmitoyl Transferase‐i Inhibition Is Not Associated With Cardiac Hypertrophy in Rats Fed a High‐fat Diet

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Why the study?

Does CPT-I inhibition combined with high-fat diets cause cardiac hypertrophy or dysfunction in normal rats?

Population

Normal rats

Comparison

CPT-I inhibitor oxfenicine combined with either… vs Untreated rats fed the same respective diets

Design

Preclinical

Follow-up

8 weeks

Authors

IOIsidore C OkereMCMargaret P. ChandlerTMTracy A McElfresh

Discussion

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Overview

High-fat diet or CPT-I inhibition spares cardiac structure and function in normal rats; leaves open effects in diseased models or humans.

Structured PICO

Does CPT-I inhibition combined with high-fat diets cause cardiac hypertrophy or dysfunction in normal rats?

P
Population
Normal rats
I
Intervention
CPT-I inhibitor oxfenicine (150 mg/kg per day) combined with either standard low-fat chow, long-chain saturated fatty acid diet, long-chain unsaturated fatty acid diet, or medium-chain fatty acid diet for 8 weeks
C
Comparator
Untreated rats fed the same respective diets
O
Outcome
Cardiac hypertrophy (left ventricular mass), end diastolic volume, and systolic functionsurrogate

Consuming a high-fat diet or inhibiting CPT-I does not result in cardiac hypertrophy or dysfunction in normal rats, despite increased cardiac triglyceride stores.

Cite This Study

Okere et al. (2006) studied this question.

synapsesocial.com/papers/6a7ef27377d355d255f007efhttps://doi.org/10.1111/j.1440-1681.2007.04545.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure2005 · 123 citations
  2. 2Effects of chronic activation of peroxisome proliferator-activated receptor-α or high-fat feeding in a rat infarct model of heart failure2005 · 85 citations
  3. 3Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation2007 · 35 citations
  4. 4Combined therapy with PPARα agonist and l-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency2006 · 20 citations
  5. 5Reactivation of Peroxisome Proliferator-activated Receptor Alpha in Spontaneously Hypertensive Rat: Age-associated Paradoxical Effect on the Heart2011 · 19 citations