Key result
Oxfenicine attenuated the rise of resting tension and improved post-hypoxic recovery of peak tension in isolated atria from fasted rats during hypoxia.
Why the study?
Does oxfenicine improve functional recovery in hypoxic isolated rat atria?
Population
Isolated rat atria from 24 h fasted and fed rats
Comparison
Oxfenicine vs Untreated isolated rat atria
Design
Preclinical
Authors
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Hypothesis-generating for metabolic modulation in hypoxic atria; leaves open translation to intact or human myocardium.
Does oxfenicine improve functional recovery in hypoxic isolated rat atria?
Oxfenicine preserves atrial function during hypoxia in fasted rats, likely through the inhibition of fatty acid oxidation.
Carregal et al. (1995) studied Hypoxia. Oxfenicine was evaluated on Hypoxic functional disturbances (resting tension, peak tension, pacemaker frequency, lactate output). Oxfenicine attenuated the rise of resting tension and improved post-hypoxic recovery of peak tension in isolated atria from fasted rats during hypoxia.
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