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August 1, 1980European Heart Journal

The mean pacing time to angina was significantly increased from 289 ± 33 s to 360 ± 35 s (P < 0.05) after oxfenicine.

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Why the study?

Does oxfenicine improve pacing time to angina and myocardial carbohydrate utilization in patients with obstructive coronary artery disease?

Population

18 patients with obstructive coronary artery disease

Comparison

Oxfenicine (L-hydroxyphenylglycine) 3-12 mg/kg vs Baseline (pre-drug)

Design

Other

Authors

GBGeoffrey BergmanInterventional / Structural CardiologyLAL AtkinsonKing's College HospitalJMJ. M. MetcalfeKing's College Hospital

Discussion

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Overview

May support metabolic modulation in angina; leaves open clinical role pending randomized trials.

Structured PICO

Does oxfenicine improve pacing time to angina and myocardial carbohydrate utilization in patients with obstructive coronary artery disease?

P
Population
18 patients with obstructive coronary artery disease
I
Intervention
Oxfenicine (L-hydroxyphenylglycine) 3-12 mg/kg
C
Comparator
Baseline (pre-drug)
O
Outcome
Pacing time to anginasurrogate

Oxfenicine increases myocardial carbohydrate extraction and reduces oxygen consumption, significantly prolonging pacing time to angina in patients with obstructive coronary artery disease.

Cite This Study

Bergman et al. (1980) studied this question.

synapsesocial.com/papers/6a82d4f84bc907ccd675a83fhttps://doi.org/10.1093/oxfordjournals.eurheartj.a061126
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia2003 · 47 citations
  2. 2Beneficial Effects of Oxfenicine on the Hypoxic Rat Atria1995 · 10 citations
  3. 3Effect of Perhexiline and Oxfenicine on Myocardial Function and Metabolism During Low-Flow Ischemia/Reperfusion in the Isolated Rat Heart2000 · 89 citations
  4. 4Effects of reducing fatty acid metabolism on mechanical function in regionally ischemic hearts1984 · 59 citations
  5. 5Acetyl-l-Carnitine and Oxfenicine on Cardiac Pumping Mechanics in Streptozotocin-Induced Diabetes in Male Wistar Rats2013 · 5 citations