Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 7, 2011Journal of Cardiovascular Pharmacology

Fenofibrate treatment prevented cardiac remodeling in young animals (2 months) but aggravated hypertrophy in older animals (6 months).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does fenofibrate prevent cardiac hypertrophy in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats in the initial stages of hypertrophy and those with established hypertrophy

Design

Preclinical

Follow-up

60 days

Authors

SPSreeja PurushothamanMSMB Mohamed SathikRNRenuka R. Nair

Discussion

Loading...

Member takes

Overview

May warrant age-specific caution in hypertensive models; leaves open PPARα modulation for human cardiac remodeling.

Structured PICO

Does fenofibrate prevent cardiac hypertrophy in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHRs) in the initial stages of hypertrophy (2 months of age) and those with established hypertrophy (6 months of age)
I
Intervention
Fenofibrate 100 mg/kg/day for 60 days
O
Outcome
Cardiac hypertrophy and remodelingsurrogate

Stimulation of PPARα with fenofibrate before metabolic remodeling prevents cardiac hypertrophy, but reactivation after metabolic adaptation aggravates it, suggesting age-dependent paradoxical effects.

Cite This Study

Purushothaman et al. (2011) studied this question.

synapsesocial.com/papers/6a865a52da4bf993812ed75fhttps://doi.org/10.1097/fjc.0b013e31822368d7
View Full Paper
Ask AI
Bookmark
Share