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July 22, 2003EndocrinologyOpen Access

Peroxisome Proliferator Activated Receptor (PPAR)α Agonists Inhibit Hypertrophy of Neonatal Rat Cardiac Myocytes

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Why the study?

Do PPAR alpha ligands inhibit endothelin-induced hypertrophy in neonatal rat cardiac myocytes?

Population

Neonatal rat cardiac myocytes stimulated with endothelin to activate the hypertrophic program in vitro

Comparison

PPAR alpha ligands (fenofibrate and WY14,643) vs Endothelin stimulation without PPAR alpha…

Design

Preclinical

Authors

FLFaquan LiangFWFeng WangSZSumei Zhang

Discussion

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Overview

Should not change practice; leaves open translation of PPARα effects from neonatal rat myocytes to clinical hypertrophy.

Structured PICO

Do PPAR alpha ligands inhibit endothelin-induced hypertrophy in neonatal rat cardiac myocytes?

P
Population
Neonatal rat cardiac myocytes stimulated with endothelin to activate the hypertrophic program in vitro
I
Intervention
PPAR alpha ligands (fenofibrate and WY14,643)
C
Comparator
Endothelin stimulation without PPAR alpha ligands, and comparison with PPAR gamma agonist rosiglitazone
O
Outcome
Hypertrophy-dependent increases in protein synthesis, cell surface area, and sarcomeric organizationsurrogate

PPAR alpha ligands suppress endothelin-induced hypertrophy in neonatal rat cardiac myocytes, suggesting potential utility in managing myocardial hypertrophy and remodeling.

Cite This Study

Liang et al. (2003) studied this question.

synapsesocial.com/papers/6a6f7904e71d69abee0809bahttps://doi.org/10.1210/en.2002-0217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo2002 · 259 citations
  2. 2Activation of peroxisome proliferator‐activated receptor‐α prevents glycogen synthase 3β phosphorylation and inhibits cardiac hypertrophy2007 · 42 citations
  3. 3Peroxisome Proliferator-Activated Receptor γ Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes2001 · 6 citations
  4. 4Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.2001 · 194 citations
  5. 5Peroxisome proliferator-activated receptor ?/? activation inhibits hypertrophy in neonatal rat cardiomyocytes2004 · 171 citations