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October 2, 2001Circulation

Peroxisome Proliferator-Activated Receptor γ Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes

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Why the study?

Do PPARγ activators inhibit cardiac hypertrophy in neonatal rat cardiac myocytes?

Population

Neonatal rat cardiac myocytes

Comparison

PPARγ activators at 10 μmol/L vs Control under cyclic 4% biaxial mechanical…

Design

Preclinical

Authors

KYKeiji YamamotoRORuri OhkiUIUichi Ikeda

Discussion

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Overview

Hypothesis-generating for PPARγ activators limiting myocyte hypertrophy; leaves open translation to in vivo or clinical settings.

Structured PICO

Do PPARγ activators inhibit cardiac hypertrophy in neonatal rat cardiac myocytes?

P
Population
Neonatal rat cardiac myocytes
I
Intervention
PPARγ activators (troglitazone and 15-deoxy-Δ12-14-prostaglandin J2 [15d-PGJ2]) at 10 μmol/L
C
Comparator
Control (vehicle/no activator) under cyclic 4% biaxial mechanical strain, angiotensin II, or phenylephrine
O
Outcome
Cardiac hypertrophy (measured by cell enlargement, total cell protein, and [3H]leucine uptake)surrogate

PPARγ activators inhibit mechanically and agonist-induced cardiac hypertrophy in neonatal rat cardiac myocytes, potentially via the NF-κB pathway.

Cite This Study

Yamamoto et al. (2001) studied this question.

synapsesocial.com/papers/6a8bda4660c8c47a9ee3eceahttps://doi.org/10.1161/hc4001.097186
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.2001 · 194 citations
  2. 2Peroxisome proliferator-activated receptor ?/? activation inhibits hypertrophy in neonatal rat cardiomyocytes2004 · 171 citations
  3. 3Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo2002 · 259 citations
  4. 4Peroxisome Proliferator Activated Receptor (PPAR)α Agonists Inhibit Hypertrophy of Neonatal Rat Cardiac Myocytes2003 · 76 citations
  5. 5Peroxisome Proliferator-Activated Receptor β/δ Activation Improves Angiotensin II-Induced Cardiac Hypertrophy in Vitro2008 · 32 citations