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January 1, 2008Clinical and Experimental Hypertension

Peroxisome Proliferator-Activated Receptor β/δ Activation Improves Angiotensin II-Induced Cardiac Hypertrophy in Vitro

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Key result

GW0742 pretreatment ameliorated Angiotensin II-induced cardiomyocyte hypertrophy and inhibited the expression of inflammatory cytokines MMP9, MMP2, and IL-1beta in vitro.

Why the study?

Does GW0742 prevent Angiotensin II-induced cardiac hypertrophy in neonatal rat cardiomyocytes?

Population

In vitro cardiomyocyte hypertrophy model from neonatal rats induced with Angiotensin II (Ang II 1 micromol x…

Comparison

GW0742 (10 micromol.L), an agonist of… vs Ang II stimulation without GW0742 pretreatment

Design

Preclinical

Follow-up

48 hours (pretreatment)

Authors

LSLi ShengPYPing YeYLYongxue Liu

Discussion

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Member takes

Overview

Supports PPARβ/δ agonism in rat cardiomyocyte hypertrophy; hypothesis-generating, requires in vivo and human validation before any clinical consideration.

Structured PICO

Does GW0742 prevent Angiotensin II-induced cardiac hypertrophy in neonatal rat cardiomyocytes?

P
Population
In vitro study of cultured neonatal rat cardiomyocytes subjected to Angiotensin II-induced hypertrophy.
I
Intervention
GW0742 (10 micromol.L(-1)), an agonist of PPARbeta/delta, pretreatment for 48h before Ang II stimulation
C
Comparator
Ang II stimulation without GW0742 pretreatment
O
Outcome
Cardiomyocyte hypertrophy (measured by surface area of myocytes, ANP and BNP mRNA expressions, and (3)H-leucine incorporation)surrogate

GW0742, a PPARbeta/delta agonist, exerts a beneficial effect on Angiotensin II-induced cardiac hypertrophy and related inflammatory responses in vitro.

Cite This Study

Sheng et al. (2008) studied Angiotensin II-induced cardiac hypertrophy. GW0742 vs. Angiotensin II stimulation alone was evaluated on Cardiomyocyte hypertrophy (surface area, ANP/BNP mRNA, 3H-leucine incorporation). GW0742 pretreatment ameliorated Angiotensin II-induced cardiomyocyte hypertrophy and inhibited the expression of inflammatory cytokines MMP9, MMP2, and IL-1beta in vitro.

synapsesocial.com/papers/6a9fa3f42048eda17b0df769https://doi.org/10.1080/10641960801945840
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.2001 · 194 citations
  2. 2Peroxisome Proliferator-Activated Receptor γ Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes2001 · 6 citations
  3. 3Peroxisome Proliferator Activated Receptor (PPAR)α Agonists Inhibit Hypertrophy of Neonatal Rat Cardiac Myocytes2003 · 76 citations
  4. 4Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin2009 · 66 citations
  5. 5Peroxisome proliferator-activated receptor ?/? activation inhibits hypertrophy in neonatal rat cardiomyocytes2004 · 171 citations