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March 12, 2002Circulation

Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo

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Why the study?

Does PPARgamma activation inhibit cardiac hypertrophy in vitro and in vivo?

Population

Neonatal rat cardiac myocytes and mice subjected to pressure overload

Comparison

PPARgamma ligands vs Untreated/control conditions; wild-type vs…

Design

Preclinical

Authors

MAMasayuki AsakawaHTHiroyuki TakanoTNToshio Nagai

Discussion

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Overview

Supports PPARgamma in hypertrophy regulation; animal data leave open human translation.

Structured PICO

Does PPARgamma activation inhibit cardiac hypertrophy in vitro and in vivo?

P
Population
Neonatal rat cardiac myocytes (in vitro) and mice (wild-type and heterozygous PPARgamma-deficient) subjected to pressure overload (in vivo)
I
Intervention
PPARgamma ligands (troglitazone, pioglitazone, and rosiglitazone in vitro; pioglitazone in vivo)
C
Comparator
Untreated/control conditions; wild-type vs heterozygous PPARgamma-deficient mice
O
Outcome
Inhibition of Ang II-induced hypertrophy (upregulation of skeletal alpha-actin and atrial natriuretic peptide genes, cell surface area) in vitro; inhibition of pressure overload-induced increases in heart weight-to-body weight ratio, wall thickness, and myocyte diameter in vivosurrogate

PPARgamma activation inhibits cardiac hypertrophy in vitro and in vivo, suggesting a critical role for the PPARgamma-dependent pathway in regulating cardiac growth.

Cite This Study

Asakawa et al. (2002) studied this question.

synapsesocial.com/papers/6a7dee2c4d9a7e00d75ca668https://doi.org/10.1161/hc1002.105225
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Also Consider

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  1. 1Expression and Function of PPARγ in Rat and Human Vascular Smooth Muscle Cells2000 · 445 citations
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  3. 3Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.1993 · 1,429 citations
  4. 4Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes1998 · 240 citations
  5. 5Insulin resistance in patients with cardiac hypertrophy1999 · 128 citations