July 29, 2005Circulation ResearchOpen Access

Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice

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Population

Cardiomyocyte-specific PPAR-gamma-knockout (CM-PGKO) mice and littermate control mice

Comparison

Cardiomyocyte-specific PPAR-gamma knockout… vs Littermate control mice without rosiglitazone…

Design

Preclinical

Authors

SDSheng Zhong DuanChinese Academy of Sciences CIChristine Y. IvashchenkoGlaxoSmithKline (United States)MRMark W. RussellPediatric Cardiology

Discussion

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Implication

Animal data suggest cardiomyocyte PPARγ inhibits hypertrophy; leaves open PPARγ-independent rosiglitazone effects for human study.

Structured PICO

Population

Cardiomyocyte-specific PPAR-gamma-knockout (CM-PGKO) mice and littermate control mice

Intervention

Cardiomyocyte-specific PPAR-gamma knockout and/or rosiglitazone treatment

Comparator

Littermate control mice without rosiglitazone treatment

Outcome

Cardiac hypertrophy and molecular pathway activation (embryonic gene expression, NF-kB activity, kinase phosphorylation)surrogate

Cardiomyocyte PPAR-gamma suppresses cardiac growth in vivo, while rosiglitazone induces cardiac hypertrophy through mechanisms at least partially independent of PPAR-gamma.

Cite This Study

Duan et al. (2005) studied this question.

synapsesocial.com/papers/6a6ff6a66ceb2bbd16dfc370 https://doi.org/10.1161/01.res.0000179226.34112.6d

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Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider