Why the study?
Do PPAR agonists reduce myocardial lipid accumulation in cardiomyocyte-specific PPARγ-knockout mice?
Population
Cardiomyocyte-specific PPARγ-knockout mice and littermate control mice undergoing standard and high fat diet.
Comparison
Rosiglitazone, pioglitazone, or fenofibrate… vs Standard diet or high fat diet alone for 6 weeks.
Design
Preclinical, randomly assigned
Follow-up
24 weeks (18 weeks diet + 6 weeks treatment)
Authors
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PPAR agonists may protect myocardium from lipotoxicity indirectly via reduced fatty acid delivery; leaves open translation beyond this mouse model.
Do PPAR agonists reduce myocardial lipid accumulation in cardiomyocyte-specific PPARγ-knockout mice?
PPAR agonists protect the myocardium from lipotoxic damage indirectly by reducing fatty acid delivery, independent of cardiomyocyte PPARγ expression.
Barbieri et al. (2012) studied this question.
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