Why the study?
Does pharmacological PPARbeta activation induce cardiac growth and angiogenesis in male C57/Bl6 mice?
Does pharmacological PPARbeta activation induce cardiac growth and angiogenesis in male C57/Bl6 mice?
Pharmacological activation of PPARbeta induces rapid, non-pathological cardiac growth and angiogenesis via direct activation of calcineurin A, suggesting a novel approach to increase cardiac muscle mass.
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Supports PPARbeta as target for cardiac growth in mice; leaves open translation to human disease.
Wagner et al. (2009) studied this question.
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