What question did this study set out to answer?

To determine the structural and functional cardiac alterations caused by chronic pharmacological inhibition of long-chain fatty acid oxidation.

January 1, 1990AJP Heart and Circulatory Physiology

Chronic inhibition of fatty acid oxidation: new model of diastolic dysfunction

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Why the study?

Does inhibition of long-chain fatty acid oxidation with 2-tetradecylglycidic acid (TDGA) induce diastolic dysfunction in male Sprague-Dawley rats?

Population

64 male Sprague-Dawley rats

Comparison

2-tetradecylglycidic acid 20 mg/kg/day by gavage… vs Comparable volume of vehicle by gavage feeding…

Design

Preclinical

Follow-up

7 or 21 days

Authors

SLS E LitwinThe Ohio State University Wexner Medical Center TRT E RayaUniversity of Arizona RGR. G. GayUnited States Department of Veterans Affairs

Discussion

Member takes

Implication

TDGA yields a rat model of hypertrophy with isolated diastolic stiffness; leaves open relevance to human metabolic HFpEF.

Key Points

To determine the structural and functional cardiac alterations caused by chronic pharmacological inhibition of long-chain fatty acid oxidation.
Male Sprague-Dawley rats (n = 64) received either 2-tetradecylglycidic acid (TDGA; 20 mg/kg/day) or vehicle via oral gavage for 7 or 21 days.
Hemodynamics, left ventricular pressures, relaxation kinetics, myocyte dimensions, myocardial triglycerides, and chamber stiffness were evaluated in conscious animals.
TDGA increased left ventricular mass, endocardial myocyte volume by 53%, epicardial myocyte volume by 65%, and myocardial triglyceride content threefold.
Left ventricular chamber stiffness constants (between 0 and 30 mmHg) and myocardial stiffness constants increased, while operating end-diastolic volumes decreased at both 7 and 21 days.
Heart rate, left ventricular systolic and end-diastolic pressures, dP/dt, and the time constant of relaxation remained unchanged across both treatment durations.

Structured PICO

Does inhibition of long-chain fatty acid oxidation with 2-tetradecylglycidic acid (TDGA) induce diastolic dysfunction in male Sprague-Dawley rats?

Population

64 male Sprague-Dawley rats

Intervention

2-tetradecylglycidic acid (TDGA) 20 mg/kg/day by gavage feeding for 7 or 21 days

Comparator

Comparable volume of vehicle by gavage feeding for 7 or 21 days

Outcome

Changes in the heart (hemodynamics, mass, myocyte volume, triglyceride content, and stiffness) resulting from inhibition of long-chain fatty acid oxidationsurrogate

Inhibition of long-chain fatty acid oxidation with TDGA in rats produces a novel model of left ventricular hypertrophy and diastolic dysfunction characterized by abnormal passive-elastic properties but preserved relaxation.

Cite This Study

Litwin et al. (1990) studied this question.

synapsesocial.com/papers/6a705dc16ceb2bbd16dfdd2d https://doi.org/10.1152/ajpheart.1990.258.1.h51

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Chronic inhibition of fatty acid oxidation: new model of diastolic dysfunction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Chronic inhibition of fatty acid oxidation: new model of diastolic dysfunction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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