July 8, 2011Circulation Cardiovascular Imaging

Fasting-Induced Myocardial Lipid Accumulation in Long-Chain Acyl-CoA Dehydrogenase Knockout Mice Is Accompanied by Impaired Left Ventricular Function

Q: What is the clinical evidence from this study?

Study design: Other. Population: Mitochondrial long-chain fatty acid β-oxidation (FAO) disorders (n=16). Intervention: Fasting in LCAD knockout mice vs. Fasting in wild-type mice. Primary outcome: Myocardial triglyceride content, LV ejection fraction, and diastolic filling rate (p=<0.01).

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Key result

Fasting in LCAD knockout mice led to increased myocardial triglyceride and ceramide content (P<0.05) and decreased left ventricular ejection fraction and diastolic filling rate (P<0.01).

Authors

ABAdrianus J. BakermansCardiac Imaging TGTom R. GeraedtsEindhoven University of Technology MWMichel van WeeghelNetherlands Metabolomics Centre

Discussion

Member takes

Implication

Raises caution for fasting in LCAD deficiency; leaves open whether lipid accumulation drives human cardiomyopathy.

PICO

Population

16 mice (8 LCAD knockout and 8 wild-type) evaluated for fasting-induced changes in cardiac morphology, function, and triglyceride storage.

Exposure / Comparator

Fasting in LCAD knockout mice vs Fasting in wild-type mice

Primary Outcome

Myocardial triglyceride content, LV ejection fraction, and diastolic filling rate, p=<0.01

Main Result

p-value: p=<0.01

Cite This Study

Bakermans et al. (2011) studied Mitochondrial long-chain fatty acid β-oxidation (FAO) disorders (n=16). Fasting in LCAD knockout mice vs. Fasting in wild-type mice was evaluated on Myocardial triglyceride content, LV ejection fraction, and diastolic filling rate (p=<0.01). Fasting in LCAD knockout mice led to increased myocardial triglyceride and ceramide content (P<0.05) and decreased left ventricular ejection fraction and diastolic filling rate (P<0.01).

synapsesocial.com/papers/6a7da238019fe016aa3396bb https://doi.org/10.1161/circimaging.111.963751

Topics

Cardiac MRI

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Fasting-Induced Myocardial Lipid Accumulation in Long-Chain Acyl-CoA Dehydrogenase Knockout Mice Is Accompanied by Impaired Left Ventricular Function

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

Topics

Fasting-Induced Myocardial Lipid Accumulation in Long-Chain Acyl-CoA Dehydrogenase Knockout Mice Is Accompanied by Impaired Left Ventricular Function

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

Also Consider

Topics

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