November 1, 1982AJP Heart and Circulatory Physiology

Metabolic and mechanical effects using L- and D-carnitine in working swine hearts

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Why the study?

Does L-carnitine improve mechanical and metabolic functions compared to D-carnitine in regionally ischemic swine hearts?

Population

17 intact, regionally ischemic swine hearts

Comparison

L-carnitine vs D-carnitine (same dosage schedule)

Design

Preclinical

Authors

ALA. J. LiedtkeUniversity Hospital of Basel SNS. H. NellisPennsylvania State University LWL WhitesellNational Institutes of Health

Discussion

Member takes

Implication

Does not support clinical use in ischemic heart disease; leaves open translation of swine metabolic benefits to human trials.

Structured PICO

Does L-carnitine improve mechanical and metabolic functions compared to D-carnitine in regionally ischemic swine hearts?

Population

17 intact, regionally ischemic swine hearts (coronary flows decreased in the anterior descending circulation by -53% delta)

Intervention

L-carnitine (average serum concentration 804 nmol/ml)

Comparator

D-carnitine (same dosage schedule)

Outcome

Differences in mechanical and metabolic functions (fatty acid metabolism and regional shortening)surrogate

L-carnitine favorably modifies oxygen consumption and global mechanical efficiency in working swine hearts compared to D-carnitine.

Cite This Study

Liedtke et al. (1982) studied this question.

synapsesocial.com/papers/6a82dedff31edfcc6410bc38 https://doi.org/10.1152/ajpheart.1982.243.5.h691

View Full Paper

Ask AI

Bookmark

Metabolic and mechanical effects using L- and D-carnitine in working swine hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metabolic and mechanical effects using L- and D-carnitine in working swine hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider