Why the study?
Does L-carnitine improve tissue levels of ATP and reduce accumulation of long chain acyl carnitine and acyl CoA in ischemic dog hearts?
Population
Dog hearts with myocardial ischemia induced by ligation of the left anterior descending coronary artery for…
Comparison
L-carnitine 100 mg/kg administered intravenously… vs Ischemic myocardium without L-carnitine…
Design
Preclinical
Follow-up
15 minutes
Authors
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L-carnitine may protect ischemic myocardium metabolically; leaves open translation to human ischemia.
Does L-carnitine improve tissue levels of ATP and reduce accumulation of long chain acyl carnitine and acyl CoA in ischemic dog hearts?
L-carnitine pretreatment in ischemic dog hearts reduces the accumulation of long chain acyl carnitine and acyl CoA while preserving ATP levels, suggesting a protective metabolic effect on ischemic myocardium.
Suzuki et al. (1981) studied this question.
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