Why the study?
Does intravenous L-carnitine improve cardiac hemodynamics in normal closed chest dogs?
Population
5 normal mongrel dogs weighing 8 to 10 Kg, anesthetized with intravenous sodium pentobarbital
Comparison
L-carnitine infused intravenously at a constant… vs Baseline (control period prior to infusion)
Design
Preclinical
Follow-up
8 minutes
Authors
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May enhance coronary flow and contractility in normal dogs; hypothesis-generating for human translation and requires clinical trials.
Does intravenous L-carnitine improve cardiac hemodynamics in normal closed chest dogs?
Intravenous L-carnitine demonstrates direct vasodilating and positive inotropic effects on the cardiovascular system in a normal canine model.
Suzuki et al. (1981) studied this question.
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