March 1, 1993AJP Heart and Circulatory Physiology
Competition between palmitate and ketone bodies as fuels for the heart: study with positron emission tomography
Key result
Infusion of 3-hydroxybutyrate significantly decreased the relative size of the early rapid phase of myocardial palmitate clearance by 28% (P<0.001), indicating reduced fatty acid oxidation.
Why the study?
Does infusion of 3-hydroxybutyrate inhibit myocardial fatty acid oxidation in vivo in humans and dogs?
Population
6 fasted human volunteers and 6 instrumented dogs
Comparison
Infusion of 3-hydroxybutyrate vs Baseline (before infusion)
Design
Other
Authors
Discussion
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Overview
May support ketone-mediated shifts in myocardial substrate use; hypothesis-generating and should not yet change practice.
Structured PICO
Does infusion of 3-hydroxybutyrate inhibit myocardial fatty acid oxidation in vivo in humans and dogs?
P
Population
6 fasted human volunteers and 6 instrumented dogs studied to assess myocardial clearance kinetics before and during 3-hydroxybutyrate infusion.
I
Intervention
Infusion of 3-hydroxybutyrate (17 mumol.kg-1 x min-1)
C
Comparator
Baseline (before infusion)
O
Outcome
Myocardial clearance kinetics of [1-11C]palmitate assessed with positron emission tomography (size, half time, and index of the early rapid phase)surrogate
Main Result
Effect estimate: -28% change
p-value: p=<0.001
Infusion of 3-hydroxybutyrate alters palmitate kinetics in vivo by decreasing myocardial long-chain fatty acid oxidation and increasing backdiffusion of nonmetabolized tracer.
Cite This Study
Vanoverschelde et al. (1993) studied Fasted state (n=12). 3-hydroxybutyrate vs. Baseline (before infusion) was evaluated on Relative size of the early rapid phase of 11C myocardial clearance (-28% change, p=<0.001). Infusion of 3-hydroxybutyrate significantly decreased the relative size of the early rapid phase of myocardial palmitate clearance by 28% (P<0.001), indicating reduced fatty acid oxidation.