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July 1, 1979AJP Heart and Circulatory Physiology

External assessment of myocardial metabolism with 11Cpalmitate in rabbit hearts

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Why the study?

Does [11C]palmitate positron emission permit noninvasive assessment of myocardial fatty acid utilization and oxygen consumption in rabbit hearts?

Population

Isolated rabbit hearts (n=11) and in vivo rabbit models (n=2 animals)

Design

Preclinical

Authors

MKMilton S. KleinWashington University in St. LouisRGRichard A. GoldsteinUniversity College LondonMWM. J. WelchInstitute of Applied Physics

Discussion

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Overview

Feasibility shown for [11C]palmitate PET in isolated hearts; leaves open translation to noninvasive human assessment of fatty acid utilization.

Structured PICO

Does [11C]palmitate positron emission permit noninvasive assessment of myocardial fatty acid utilization and oxygen consumption in rabbit hearts?

P
Population
Isolated rabbit hearts (n=11) and in vivo rabbit models (n=2 animals)
I
Intervention
[11C]palmitate (100 muCi) administration via intra-atrial injection or in isolated hearts, followed by positron emission assay
O
Outcome
Correlation of 11C-radioactivity clearance with tension-time index (TTI) and peak dP/dtsurrogate

Residue detection of [11C]palmitate allows for the external assessment of global myocardial metabolism and reflects changes in substrate utilization, demonstrating feasibility for PET imaging.

Cite This Study

Klein et al. (1979) studied this question.

synapsesocial.com/papers/6a952ff2b1a163ea01769485https://doi.org/10.1152/ajpheart.1979.237.1.h51
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Competition between palmitate and ketone bodies as fuels for the heart: study with positron emission tomography1993 · 25 citations
  2. 2Delineation of myocardial oxygen utilization with carbon-11-labeled acetate.1987 · 241 citations
  3. 3Effects of inhibition of fatty acid oxidation on myocardial kinetics of 11C-labeled palmitate.1989 · 24 citations
  4. 4Kinetic models for analysing myocardial [11C]palmitate data2009 · 22 citations
  5. 5Effect of flow-independent reduction of metabolism on regional myocardial clearance of 11C-palmitate.1982 · 85 citations