October 1, 2003AJP Heart and Circulatory Physiology

β-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content

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Why the study?

Does beta-hydroxybutyrate inhibit myocardial fatty acid oxidation in anesthetized pigs?

Structured PICO

Does beta-hydroxybutyrate inhibit myocardial fatty acid oxidation in anesthetized pigs?

Population

Anesthetized pigs (n=20 total; 6 untreated, 7 fat emulsion, 7 fat emulsion + beta-hydroxybutyrate)

Intervention

Intravenous infusion of beta-hydroxybutyrate (25 micromol.kg-1.min-1) for 60 min, in addition to fat emulsion and continuous infusion of [3H]palmitate

Comparator

Intravenous infusion of fat emulsion alone (n=7) or untreated (n=6), both receiving continuous infusion of [3H]palmitate

Outcome

Myocardial fatty acid oxidation measured from the cardiac production of 3H2Osurrogate

Beta-hydroxybutyrate inhibits myocardial fatty acid uptake and oxidation in vivo independent of changes in malonyl-CoA content.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May modulate myocardial substrate use; leaves open translation from porcine model to human disease.

Cite This Study

Stanley et al. (2003) studied this question.

synapsesocial.com/papers/6a0662e13f8bf83a443dd976 https://doi.org/10.1152/ajpheart.00332.2003

View Full Paper

Ask AI

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β-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content

Structured PICO

Discussion

Implication

Cite This Study

β-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider