Why the study?
Does beta-hydroxybutyrate infusion modify oxidative metabolism and phosphorylation potential in the canine heart in vivo?
Does beta-hydroxybutyrate infusion modify oxidative metabolism and phosphorylation potential in the canine heart in vivo?
Beta-hydroxybutyrate modulates cardiac phosphorylation potential in vivo, likely through increasing mitochondrial NADH concentration, without altering cardiac function or oxygen consumption.
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HBA effects on canine energetics should not guide therapy; leaves open clinical translation in human heart disease.
Kim et al. (1991) studied this question.
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