Key result
Administration of HBOC increased myocardial oxygen consumption from 7.2 to 15 ml O2/min (p<0.01) and shifted cardiac metabolism from free fatty acids to lactate and glucose in conscious dogs.
Why the study?
Does bovine polymerized hemoglobin-based oxygen carrying solution alter myocardial oxygen consumption and substrate use in conscious dogs?
Does bovine polymerized hemoglobin-based oxygen carrying solution alter myocardial oxygen consumption and substrate use in conscious dogs?
Absolute Event Rate: 15% vs 7.2%
p-value: p=<0.01
In a canine model, HBOC administration increases coronary blood flow and myocardial oxygen consumption while shifting cardiac metabolism toward lactate and glucose, independent of hemodynamic changes.
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Hypothesis-generating for HBOC effects on cardiac metabolism; human studies needed before clinical consideration.
Loke et al. (2000) studied Conscious dogs (animal model) (n=9). Bovine polymerized hemoglobin-based oxygen carrying (HBOC) solution vs. Baseline / Angiotensin II was evaluated on Myocardial oxygen consumption (MVO2) (p=<0.01). Administration of HBOC increased myocardial oxygen consumption from 7.2 to 15 ml O2/min (p<0.01) and shifted cardiac metabolism from free fatty acids to lactate and glucose in conscious dogs.
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