Key result
Stimulation of carbohydrate metabolism with glucose and beta-pyridyl carbinol or dichloroacetate reduced myocardial oxygen consumption by 25% and 16%, respectively, in closed-chest dogs.
Why the study?
Does changing myocardial metabolism from lipid to carbohydrate utilization reduce myocardial oxygen consumption in closed-chest dogs?
Does changing myocardial metabolism from lipid to carbohydrate utilization reduce myocardial oxygen consumption in closed-chest dogs?
Shifting myocardial metabolism from lipid to carbohydrate utilization significantly reduces myocardial oxygen consumption in a canine model.
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Animal data preclude clinical use of carbohydrate stimulation to lower MVO2; leaves open translation to human ischemia or HF.
Kahles et al. (1982) studied this question. Stimulation of carbohydrate metabolism (glucose and beta-pyridyl carbinol or dichloroacetate) vs. Control conditions (predominantly lipid utilization) was evaluated on Myocardial oxygen consumption (MVO2). Stimulation of carbohydrate metabolism with glucose and beta-pyridyl carbinol or dichloroacetate reduced myocardial oxygen consumption by 25% and 16%, respectively, in closed-chest dogs.
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